ArticleMikrochimica acta2026
Dual-form iron on carbon nanohorns for wide-pH-range electrochemical sensing of levodopa.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Levodopa is a first-line therapeutic agent for Parkinson's disease, and real-time monitoring of its plasma concentration is crucial for optimizing personalized treatment strategies. In this study, iron/carbon nanohorn composites (Fe/CNHs(2)) featuring a dual-form Fe structure, in which atomically or sub-nanocluster dispersed Fe species coexist with Fe nanoparticles, were synthesized via a one-step positive-pressure arc-discharge method. The fabricated Fe/CNHs(2)-based sensing electrode exhibited excellent electrocatalytic activity toward levodopa, achieving a high sensitivity of 0.062 µA µM⁻¹ and a low detection limit of 0.75 µM. Moreover, the sensor enabled stable levodopa detection over a broad pH range of 3.6-9.5. Kinetic studies revealed that the wide pH tolerance originated from the enhanced structural stability provided by strong Fe-C interfacial interactions, together with an adsorption-controlled reaction process in which the rate-determining step showed limited dependence on proton concentration. Theoretical calculations further confirmed that the introduction of Fe active centers substantially decreased the reaction energy barrier. This work provides a new design strategy for metal-carbon composites with dual-functional synergy, and the developed sensor holds considerable potential for monitoring levodopa levels during Parkinson's disease treatment.
Indexed as
Identifiers
42700267What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.