ArticleMikrochimica acta2026
Ultrasonic spray pyrolysis and electro-nanofabrication of carbon-gold-based biosensor for circulating tumor cell detection.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The development of an ultrasensitive electrochemical biosensor for the label-free detection of HER2-positive breast cancer cells is reported. The developed platform leverages a novel hierarchical nanoarchitecture to achieve superior analytical performance. The nanofabricated system was constructed by depositing a carbon-gold nanoparticle (C-AuNP) layer on a fluorine-doped tin oxide (FTO) electrode via ultrasonic spray pyrolysis, in the first step. The process was followed by the electrochemical growth of gold nanostructures (AuNS) to form a conductive C-AuNP@AuNS nanocomposite. This tailored nanofabrication, dramatically enhanced the electrode's conductivity and provided an optimal substrate for bioreceptor immobilization. The surface was functionalized with Herceptin antibody for specific cell capture. Quantitative performance was evaluated using electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The biosensor demonstrated a wide linear response from 2.5 × 10
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