ArticleInternational orthopaedics2026
Neglected infected Charcot neuroarthropathy of the ankle: limb salvage using a one-stage reconstruction by distraction histogenesis principles.
Article in International orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionNeglected Infected Charcot neuroarthropathy (CN) of the ankle remains one of the most challenging problems in orthopaedic surgery. Traditionally, below-knee amputation (BKA) has been regarded as a common approach for these complex cases, reflecting the morbidity associated with prolonged and often unsuccessful reconstruction. However, advances in the principles of distraction histogenesis and circular external fixation offer a feasible option for limb salvage. PATIENTS AND
methodsWe report our experience with a specialized management protocol characterized by a one-stage procedure, the "corticotomy-first" technique, and non-radical debridement, applied in a series of 55 patients with Eichenholtz stage III Charcot neuroarthropathy of the ankle. Osteomyelitis was suspected clinically and radiographically in all patients, with active infection present in 45.5% of cases at the time of reconstruction and the remainder demonstrating chronic quiescent osteomyelitis.
resultsBy leveraging the angiogenic potential of distraction histogenesis principles, functional weight-bearing and limb preservation were achieved in the large majority of patients, including those with chronic ulceration, wheelchair dependency, and multi-drug resistant infection. Limb salvage was achieved in 52 of 55 patients (94.5%), radiographic union in 48 patients (87.3%), and independent ambulation in 50 patients (90.9%).
conclusionWe present our clinical rationale together with representative cases that illustrate this technique as an alternative reconstructive strategy for limb salvage in Neglected Infected Charcot neuroarthropathy of the ankle.
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