ArticleMedicine2026
Association between alpha-1-acid glycoprotein and serum uric acid in young and middle-aged US women: A cross-sectional study on the mediating role of the triglyceride-glucose index.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Evidence on the association between alpha-1-acid glycoprotein (AGP), a systemic inflammatory marker, and serum uric acid (SUA) remains limited, particularly among young and middle-aged women. Using cross-sectional data from 614 US women aged 20 to 49 years from the 2015 to 2018 National Health and Nutrition Examination Survey, we assessed the AGP-SUA relationship and the mediating role of the triglyceride-glucose index using multiple linear regression, smooth curve fitting, and mediation analysis. After full adjustment, each 1 g/L increase in AGP was associated with a 0.68 mg/dL increase in SUA (β = 0.68, 95% confidence interval: 0.28-1.09, P = .001). A significant dose-response trend was observed across AGP tertiles (P for trend = .003). The triglyceride-glucose index mediated 24.52% of this association. Among several inflammatory markers, AGP showed the strongest correlation with SUA (ρ = 0.27) and the highest predictive value for hyperuricemia, although the discriminative ability was modest (AUC = 0.641). Elevated AGP is independently linked to higher SUA levels, partly through insulin resistance, highlighting AGP as a relevant inflammatory marker and the interplay between inflammation and metabolism in female hyperuricemia.
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