ReviewRegenerative biomaterials2026
Physical cues influence the construction of the osteoimmune microenvironment: focus on the hematoma period.
Review in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Hematoma formation represents one of the earliest biological events during bone healing after bone injury or biomaterial implantation, a process that involves coagulation, provisional matrix formation, innate immune activation and early adaptive immune signaling. During this stage, the hematoma is rapidly infiltrated by neutrophils, monocytes/macrophages, dendritic cells and lymphocytes, which collectively construct the initial osteoimmune microenvironment that modulates subsequent angiogenesis, osteogenesis and osseointegration. Therefore, a systematic elucidation of the hematoma formation process and the regulatory factors governing hematoma behavior provides an important foundation for designing immunomodulatory bone implants. However, most current research has focused primarily on the modulation of macrophages by surface characteristics, relying heavily on simplified
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