ArticleResuscitation plus2026
Observational study: Temporal dynamics of lipoprotein(a) after out-of-hospital cardiac arrest: The Biobank Working Group.
Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
Background: Out-of-hospital cardiac arrest (OHCA) is a major cause of death in the USA and Europe, with survival rates around 10%. Lipoprotein(a) [Lp(a)] is an established cardiovascular risk factor, but its temporal profile following OHCA is unknown. Methods: In this retrospective study at a tertiary cardiac arrest center, 50 adult patients with OHCA of presumed cardiac origin were included and stratified by 6-month neurological outcome (CPC 1-2 vs. CPC 3-5). Longitudinal Lp(a) concentrations were analyzed using a linear mixed-effects model with fixed effects for time point, neurological outcome, and their interaction. Exploratory logistic regression assessed associations between Lp(a) at ROSC and neurological outcome. Results: 26 patients had a favorable outcome, and 22 had an unfavorable outcome (two patients were excluded after analysis due to problems with the sample). Baseline characteristics were similar, except for longer low-flow duration ( Conclusion: Lp(a) exhibits a time-dependent trajectory after OHCA that differs by neurological outcome. While baseline levels are not predictive, patients with unfavorable outcomes show a significant decline over time, suggesting a dynamic response possibly linked to disease severity.
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