Evidence map›Paper›PMID 42699542›Full record

ArticleiScience2026

Tetrazine-based bioorthogonal reactions to image hypoxia in cancer cells.

Sara Boumya, Chiara Boero, Edoardo De Luigi, Federica Foglietta, Gustavo Ferreira-Alves, Daniele Mancardi, Barbara Lupo, Francesca Spyrakis, Loretta Lazzarato, Marta Serafini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sara BoumyaDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Chiara BoeroDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Edoardo De LuigiDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Federica FogliettaDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Gustavo Ferreira-AlvesDepartment of Neurosciences "Rita Levi Montalcini", University of Turin, 10125 Turin, Italy.
Daniele MancardiDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, TO, Italy.
Barbara LupoDepartment of Oncology, University of Turin, 10060 Candiolo, TO, Italy.
Francesca SpyrakisDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Loretta LazzaratoDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Marta SerafiniDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Suboptimal oxygen supply in solid tumors controls a variety of cancer hallmarks and impairs responsiveness to anticancer treatments. Yet, tools to visualize hypoxia in cancer are still limited. Here we present an application of the tetrazine-dienophile inverse-electron demand Diels-Alder (IEDDA) reaction for hypoxia visualization. In this approach,

Indexed as

3D cellular modelsbystander effectclick chemistryfluorescencehypoxiatetrazine bioorthogonal reactions

Identifiers

PMID42699542
PMCPMC13543800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.