Evidence map›Paper›PMID 42699387›Full record

ArticleJournal of biomedical optics2026

Effects of surgical resection on tissue autofluorescence lifetime signatures in head and neck cancer: implications for intraoperative tumor margin assessment.

Farzad Fereidouni, Willy Ju, Sarah Rezapourdamanab, Dena Sayrafi, Mohamed Abul Hassan, Brent Weyers, Xiangnan Zhou, Julien Bec, Dorina Gui, Andrew Birkeland and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Farzad FereidouniEmory University, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, United States.
Willy JuEmory University, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, United States.ORCID https://orcid.org/0009-0001-6064-2836
Sarah RezapourdamanabEmory University, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, United States.
Dena SayrafiEmory University, Department of Pathology and Laboratory Medicine, Atlanta, Georgia, United States.ORCID https://orcid.org/0009-0007-9856-4099
Mohamed Abul HassanUniversity of California, Davis, Department of Biomedical Engineering, Davis, California, United States.ORCID https://orcid.org/0000-0002-3076-8075
Brent WeyersUniversity of California, Davis, Department of Biomedical Engineering, Davis, California, United States.
Xiangnan ZhouUniversity of California, Davis, Department of Biomedical Engineering, Davis, California, United States.ORCID https://orcid.org/0000-0002-6715-5176
Julien BecUniversity of California, Davis, Department of Biomedical Engineering, Davis, California, United States.ORCID https://orcid.org/0000-0003-1222-4071
Dorina GuiUniversity of California, Davis, Department of Pathology and Laboratory Medicine, Davis, California, United States.
Andrew BirkelandUniversity of California, Davis, School of Medicine, Department of Otolaryngology Head and Neck Surgery, Davis, California, United States.
Laura MarcuUniversity of California, Davis, Department of Biomedical Engineering, Davis, California, United States.ORCID https://orcid.org/0000-0003-2369-0748

Funding

TRD3: Data Analytics and Intelligent Systems (AI-ML-DL-Visualization)P41EB032840 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Griffith R. Harsh, Laura Marcu · 2022 to 2026
$6.7M
Fluorescence Lifetime Imaging/Spectroscopy System For Robotic Cancer Surgery GuidanceR01CA187427 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BIRKELAND, ANDREW CHARLES, MARCU, LAURA · 2014 to 2025
$4.6M
GigaFIBI; rapid, large-format histology-resolution imaging for Intraoperative assessment of breast lumpectomy marginsR01CA277527 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Farzad Fereidouni · 2023 to 2026
$2.4M
NCI NIH HHS R01 CA187427NCI NIH HHS R01 CA277527NIBIB NIH HHS P41 EB032840
6 · The paper itself

Abstract

Significance: Accurate identification of residual tumor during head and neck cancer surgery is essential for preventing local recurrences and improving patient outcomes, yet current methods for intraoperative margin assessment remain limited. Fluorescence lifetime imaging (FLIm), a label-free optical technique, has shown strong potential for distinguishing cancerous from noncancerous tissue Aim: The aim is to characterize how fluorescence lifetime properties change between Approach: A custom fiber-based, point-scanning FLIm system with phasor-based analysis was used to characterize fluorescence lifetime features Results: Resection-induced changes in decay dynamics and fluorescence lifetime values varied by anatomy: oral tongue and tonsil showed reduced contrast Conclusions: Surgical resection substantially alters autofluorescence signatures in an anatomy-dependent manner, emphasizing the need to train and validate diagnostic algorithms independently for

Indexed as

Head and Neck NeoplasmsOptical ImagingFemaleHumansMaleMargins of ExcisionNeoplasm, Residualhead and neck cancerintraoperative margin assessmentlabel-free imaging

Identifiers

PMID42699387
PMCPMC13544624

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.