Evidence map›Paper›PMID 42699321›Full record

ArticleiScience2026

The CNNM-binding interface drives PRL-3-dependent tumor progression in

Jeffery T Jolly, Karoline Felisbino, Luba Mahbub, Majd A Al-Hamaly, Meixi Jin, Caroline N Smith, Guennadi Kozlov, Kalle Gehring, Jessica S Blackburn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeffery T JollyDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.
Karoline FelisbinoDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.
Luba MahbubDepartment of Biochemistry, McGill University, Montreal, QC, Canada.
Majd A Al-HamalyMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Meixi JinDepartment of Biochemistry, McGill University, Montreal, QC, Canada.
Caroline N SmithDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.
Guennadi KozlovDepartment of Biochemistry, McGill University, Montreal, QC, Canada.
Kalle GehringDepartment of Biochemistry, McGill University, Montreal, QC, Canada.
Jessica S BlackburnDepartment of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY, USA.

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Jennifer F Rogers · 2013 to 2026
$38.3M
The Phosphatase PRL3 as a MYC Target and Pro-Survival Oncogene in Acute Lymphoblastic LeukemiaR37CA227656 · NCI · UNIVERSITY OF KENTUCKY · PI BLACKBURN, JESSICA S. · 2018 to 2024
$2.4M
NCI NIH HHS P30 CA177558NCI NIH HHS R37 CA227656
6 · The paper itself

Abstract

Phosphatase of regenerating liver 3 (PRL-3) is a cancer-associated protein linked to tumor progression, metastasis, and poor patient outcomes, but the mechanism underlying its oncogenic activity remains unresolved. PRL-3 functions both as a phosphatase and as a binding partner of CNNM magnesium transporters, raising the question of which activity drives cancer progression. Here, we combine structure-guided separation-of-function mutants with biochemical and structural analyses,

Indexed as

invasionmagnesium transportmetastasisPRL phosphatasesPTP4ArhabdomyosarcomaT cell acute lymphoblastic leukemiazebrafish

Identifiers

PMID42699321
PMCPMC13544316

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.