Evidence map›Paper›PMID 42699291›Full record

ArticleToxicology reports2026

Cytotoxicity evaluation, porosity and physicochemical study of bioactive glass nanocomposites for tissue engineering.

Mohammad Shokrzadeh, Nazanin Farhadyar, Elahe Gharekhani, Fereshteh Fathi, Masoumeh Eslamifar

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Article in Toxicology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mohammad ShokrzadehDepartment of Toxicology-Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Nazanin FarhadyarDepartment of Chemistry, Islamic Azad University, Varamin-pishva Branch, Varamin, Iran.
Elahe GharekhaniDepartment of Toxicology-Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Fereshteh FathiDepartment of Toxicology-Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Masoumeh EslamifarDepartment of environmental health engineering, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoscale bioactive glasses have been developed as regenerative materials for tissue engineering, due to their biocompatibility, osteoconductivity, antibacterial properties and abilities for hard tissue formation. In this work, nano bioactive glass/alginate (n-BG/Alg) and nano bioactive glass/polyethylene glycole (n-BG/PEG) as nanocomposite scaffolds were synthesized via facile method and physicochemical properties compared with nano bioactive glass. To characterize the nanocomposites, Fourier Transform Infrared (FT-IR), X-ray powder Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), and Dispersive X-ray Analysis (EDX) were performed. The results showed desired interaction of polymers with nano bioactive glass and the size was estimated. The swelling ability and porosity of the scaffolds were evaluated and the results showed lower swelling and porosity percentage for composites compared to the nano bioactive glass scaffold. The cytocompatibility of nanocomposites were also evaluated using Methyl Thiazolyl-Tetrazolium (MTT) (3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide) assay. The doses of 5, 15, 25, 50, and 100 μg/mL of n-BG, n-BG/PEG and n-BG/Alg were studied to determine the survival rate of Human Gingival Fibroblast (HGF) cells. The results showed a significant difference (p˂0.001) compared to the positive control group in high concentrations during 48 h. The MTT assay confirms that the scaffolds have biocompatibility.

Indexed as

AlginateCompositeMTT assayNano bioactive glassTissue engineering

Identifiers

PMID42699291
PMCPMC13542929

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.