ArticleOncology letters2026
Efficacy and safety of ICI-based triple combination therapy for gene-negative advanced lung adenocarcinoma.
Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to evaluate the efficacy and safety of immune checkpoint inhibitors (ICIs) combined with anti-angiogenic agents and chemotherapy regimens as first-line treatment for gene-negative advanced lung adenocarcinoma, a retrospective analysis was performed on the clinical data of patients with driver gene-negative advanced lung adenocarcinoma who received the ICI-Based Triple Combination regimen at The Sixth Affiliated Hospital (School of Medicine, South China University of Technology, Foshan, China) between January 2022 and December 2024. Among the enrolled patients, the objective response rate was 58.3%, and the disease control rate was 83.3%. The median progression-free survival was 25.4 months [95% confidence interval (CI): 12.7-38.0 months], and the median overall survival was 26.6 months (95% CI: 21.3-31.8 months). The most common treatment-related adverse events were hematological toxicity (58.3%), followed by nausea and vomiting (50.0%), fatigue and anorexia (33.3%), muscle pain (33.3%) and chest tightness with shortness of breath (33.3%). All symptoms improved after symptomatic treatment. The present study showed that the ICI-based triple combination regimen exhibited promising antitumor activity and a manageable safety profile in patients with driver gene-negative advanced lung adenocarcinoma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.