Evidence map›Paper›PMID 42699154›Full record

ArticleAging brain2026

Coagulation factor XII deficiency alleviates vascular dysfunction and cognitive impairment in a mouse model of cerebral β-amyloidosis and cerebral amyloid angiopathy.

Marie Rouault, Diana Rita Kindler, Ruiqing Ni, Luca Liberale, Raoul Seiler, Giovanna D Ielacqua, Roger Nitsch, Christopher Pryce, Giovanni G Camici, Luka Kulic and 1 more

Abstract read
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In one paragraph

Article in Aging brain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marie RouaultInstitute for Biomedical Engineering, University of Zurich and ETH, Zurich, Zurich, Switzerland.
Diana Rita KindlerInstitute for Biomedical Engineering, University of Zurich and ETH, Zurich, Zurich, Switzerland.
Ruiqing NiInstitute for Biomedical Engineering, University of Zurich and ETH, Zurich, Zurich, Switzerland.
Luca LiberaleAOM-IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Raoul SeilerInstitute for Biomedical Engineering, University of Zurich and ETH, Zurich, Zurich, Switzerland.
Giovanna D IelacquaDepartment of Animal Phenotyping, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany.
Roger NitschZurich Neuroscience Center (ZNZ), Zurich, Switzerland.
Christopher PryceZurich Neuroscience Center (ZNZ), Zurich, Switzerland.
Giovanni G CamiciCenter for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
Luka KulicZurich Neuroscience Center (ZNZ), Zurich, Switzerland.
Jan KlohsInstitute for Biomedical Engineering, University of Zurich and ETH, Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amyloid-β (Aβ) can activate the factor XII (FXII)-driven contact system, which exerts several downstream effects on Alzheimer's disease (AD) pathology associated with cognitive impairment. Here, using genetically modified FXII deficient mice crossed with arcAβ mice, we show that genetic deletion of FXII ameliorates β-amyloidosis-mediated susceptibility to arterial thrombus formation, blood-brain barrier leakage, and cerebral microbleed load. Furthermore, we show that genetic deletion of FXII improves cognitive deficits, without affecting Aβ deposition. Thus, the FXII-driven contact system constitutes an important pathway contributing to vascular dysfunction and cognitive impairment in AD, independent of Aβ neuropathology, with important implications for the diagnosis and treatment of the disease.

Indexed as

Alzheimer's diseaseBlood-brain barrierCerebral microbleedsCoagulationHageman factorThrombosisVascular dysfunction

Identifiers

PMID42699154
PMCPMC13543942

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.