Chemical profiling of vegetable polyphenols reveals matrix-dependent inhibition of heterocyclic amine formation in charcoal-grilled pork.

Shang-Ming Huang, Cheng-Hong Hsieh, Kai-Ching Teng, Wei-Lun Hung, Kuo-Chiang Hsu

Abstract read

In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shang-Ming HuangDepartment of Nutrition, China Medical University, No.100, Sec.1, Jingmao Rd., Beitun Dist., Taichung City 406040, Taiwan.

Cheng-Hong HsiehDepartment of Nutrition, China Medical University, No.100, Sec.1, Jingmao Rd., Beitun Dist., Taichung City 406040, Taiwan.

Kai-Ching TengDepartment of Nutrition, China Medical University, No.100, Sec.1, Jingmao Rd., Beitun Dist., Taichung City 406040, Taiwan.

Wei-Lun HungSchool of Food Safety, Taipei Medical University, No.250, Wuxing St., Xinyi Dist., Taipei City 110, Taiwan.

Kuo-Chiang HsuDepartment of Nutrition, China Medical University, No.100, Sec.1, Jingmao Rd., Beitun Dist., Taichung City 406040, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Twelve commonly consumed vegetables were screened for heterocyclic amine (HCA) inhibition in charcoal-grilled pork. Ethanolic extracts were evaluated for antioxidant capacity, and polyphenol composition was profiled by UPLC-MS/MS. Principal component analysis identified sweet potato leaves, water spinach, and coriander as the top candidates. HCA inhibition was assessed under three systems: direct marination (1%), commercial barbecue sauce, and homemade barbecue sauce. Inhibition was matrix-dependent (42.85-92.74%), with coriander achieving 92.74% under direct marination and sweet potato leaves 76.78% in homemade sauce. Molecular docking predicted ellagic acid and chlorogenic acid binding near the myosin actin-binding cleft. These findings suggest that HCA mitigation is associated with polyphenol composition and sauce matrix chemistry rather than antioxidant capacity alone, while the docking results provide a testable hypothesis regarding possible polyphenol-myosin interactions.

Indexed as

Charcoal-grilled porkHeterocyclic aminesMolecular dockingPolyphenol profilingSauce matrixUPLC-MS/MS

Identifiers

PMID42699119

DOI10.1016/j.fochx.2026.104332

PMCPMC13543979

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.