Evidence map›Paper›PMID 42699116›Full record

ReviewJournal of pharmaceutical analysis2026

Emerging natural product development strategies drive the therapeutic potential exploration and clinical translation of hydroxysafflor yellow A.

Haonan Zhu, Xiao Ni, Zhe Yu, Si Liang, Yi Qiu, Jun Huang, Tao Tang, Yang Wang, En Hu, Teng Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haonan ZhuDepartment of Integrated Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xiao NiDepartment of Neurology, Xiangya Jiangxi Hospital, Central South University, Nanchang, 410008, China.
Zhe YuDepartment of Integrated Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Si LiangThe College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, China.
Yi QiuDepartment of Integrated Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jun HuangDepartment of Integrated Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Tao TangDepartment of Integrated Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yang WangDepartment of Integrated Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
En HuDepartment of Integrated Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.
Teng LiDepartment of Integrated Chinese Medicine, Xiangya Hospital, Central South University, Changsha, 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydroxysafflor yellow A (HSYA) is a structurally unique quinochalcone di-C-glycoside derived from safflower that exhibits broad-spectrum therapeutic activities, including cardiovascular protective, neuroprotective effects, anti-inflammatory, and antioxidant. As the principal active component in approved clinical injections, HSYA has demonstrated notable efficacy in acute ischemic stroke (IS). Recent breakthroughs in elucidating its biosynthetic pathway have enabled semi-synthetic and

Indexed as

Clinical translationHydroxysafflor yellow ANatural product medicinePharmacological mechanismsStrategic innovations

Identifiers

PMID42699116
PMCPMC13543958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.