Evidence map›Paper›PMID 42699107›Full record

ArticleiScience2026

TNFα-dependent modulation of WT1-MMP9 regulatory axis links developmental and inflammatory pathways in glaucoma.

Tahseen Ahmed, Jyotishman Sarma, Meha Kabra, Shantanu Saha Roy, Samir Bera, Arun Kumar Mishra, Diganta Roy, Sayani Bagchi, Goutham Pyatla, Ashish Mishra and 6 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tahseen AhmedBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.
Jyotishman SarmaBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.
Meha KabraBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Shantanu Saha RoyBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.
Samir BeraBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Arun Kumar MishraBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.
Diganta RoyBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.
Sayani BagchiBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.
Goutham PyatlaBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Ashish MishraBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Sudipta ChakrabortyBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.
Anil K MandalBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Rohit C KhannaBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Mahua MaulikBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.
Subhabrata ChakrabartiBrien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India.
Moulinath AcharyaBiotechnology Research Innovation Council-National Institute of Biomedical Genomics (BRIC-NIBMG), P.O: N.S.S, Kalyani, West Bengal 741251, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucomas are heterogeneous optic neuropathies associated with extracellular matrix dysregulation, abnormal ocular morphogenesis, and inflammatory signaling. Targeted deep sequencing of 586 primary congenital glaucoma (PCG) cases and 1,757 controls identified rare pathogenic variants in multiple genes, including

Indexed as

anterior segment dysgenesisextracellular matrix dysregulationglaucomainflammationregulatory networktranscription factorzebrafish

Identifiers

PMID42699107
PMCPMC13542613

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.