ArticleCurrent developments in nutrition2026
Specific Collagen Peptides Support Postprandial Metabolic Health by Modulating Incretin Hormones, Gastric Transit, and Glycemic Control in Participants with Normoglycemia and Prediabetes.
Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06789263 (Clinical Study to Evaluate the Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile, Gastric Emptying and GLP-1 Release in Normoglycemic and Prediabetic Subjects), which is not on this map. Not yet cited in PubMed.
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Clinical Study to Evaluate the Effect of a Collagen Hydrolysate on Postprandial Blood Glucose Profile, Gastric Emptying and GLP-1 Release in Normoglycemic and Prediabetic Subjects: Randomized, Double-blind, Placebo-controlled, Cross-over Design
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Abstract
Background: Nutritional preload strategies can improve postprandial glycemic control through modulation of incretin secretion. We previously identified specific collagen peptides (CP; Nextida GC) that stimulate glucagon-like peptide-1 (GLP-1) secretion in vitro and improve postprandial glycemic responses in preclinical models and a pilot human study. Objectives: This study aims to investigate the effects of a CP preload on postprandial glycemic control and to characterize the associated hormonal and physiological responses in participants with normoglycemia or prediabetes. Methods: In a randomized, double-blind, placebo-controlled, crossover study, 30 participants (12 normoglycemic and 18 prediabetic) ingested 10 g CP or placebo 30 min before a standardized carbohydrate-rich meal (preload phase). Plasma glucose, serum insulin, C-peptide, GLP-1, and glucose-dependent insulinotropic polypeptide (GIP) concentrations were measured during the preload and postprandial periods. As a potential physiological mechanism, gastric transit was assessed via the gastric residence time of an indigestible capsule. Results: During the preload phase, CP significantly increased insulin and incretin levels (GLP-1 and GIP) compared with placebo (all Conclusions: A 10 g preload of CP improved postprandial glycemic control without increasing overall postprandial insulin exposure. These effects were accompanied by early stimulation of insulin and incretin hormones and, in individuals with prediabetes, prolonged gastric residence time. The findings suggest that CP may support healthy postprandial metabolic regulation through complementary hormonal and physiological mechanisms.This study was registered at clinicaltrials.gov as NCT06789263.
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