ArticleFrontiers in cardiovascular medicine2026
The impact of lipoprotein(a) determination in cardiovascular risk stratification among people living with HIV.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Human immunodeficiency virus (HIV) infection has become a chronic condition due to antiretroviral therapy (ART), which has increased life expectancy but is also associated with a higher burden of cardiovascular disease (CVD) in people living with HIV (PLHIV). Lipoprotein(a) [Lp(a)] is an independent cardiovascular risk biomarker; however, its role in PLHIV remains unclear. This study evaluated the relationship between Lp(a) and cardiovascular risk and explored its association with subclinical coronary artery disease. Methods: Cross-sectional study included PLHIV aged ≥40 years on stable ART with sustained viral suppression. Individuals with prior cardiovascular events or type 1 diabetes or long-standing type 2 diabetes (≥10 years) were excluded. Lp(a) levels and clinical data were collected. Cardiovascular risk was estimated using validated clinical scores; participants with ≥10% risk underwent coronary computed tomography angiography (CTA) to assess coronary anatomy. Results: A total of 69 patients were included (81% male; mean age 54 years). The median Lp(a) level was 23.4 nmol/L (IQR: 8.2-81.6; mean: 66.7 nmol/L); 29% had ≥75 nmol/L and 23% ≥ 105 nmol/L. A non-significant inverse association was observed between Lp(a) levels and ART duration ( Conclusions: In this cohort of virologically suppressed PLHIV, a non-significant inverse trend (
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