Evidence map›Paper›PMID 42699063›Full record

ArticleFrontiers in cardiovascular medicine2026

The impact of lipoprotein(a) determination in cardiovascular risk stratification among people living with HIV.

Carmen Ramos Alejos-Pita, Diego José Rodríguez Torres, Tatiana Mata Forte, Beatriz Tendero de la Asunción, Joaquín Enrique Gómez Sanz, Juan José Reyes Luján, Matteo Romano, Edurne López Soberón, Francisco Javier Membrillo de Novales, Miriam Estébanez Muñoz

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Carmen Ramos Alejos-PitaDepartment of Cardiology, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Diego José Rodríguez TorresDepartment of Cardiology, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Tatiana Mata ForteCBRN and Department of Infectious Diseases, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Beatriz Tendero de la AsunciónGeneral Biochemistry Section, Department of Clinical Analysis, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Joaquín Enrique Gómez SanzGeneral Biochemistry Section, Department of Clinical Analysis, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Juan José Reyes LujánResearch Section, Department of Education, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Matteo RomanoDepartment of Radiology, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Edurne López SoberónDepartment of Cardiology, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Francisco Javier Membrillo de NovalesCBRN and Department of Infectious Diseases, Central Defense Hospital Gómez Ulla, Madrid, Spain.
Miriam Estébanez MuñozUniversity of Alcalá, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Human immunodeficiency virus (HIV) infection has become a chronic condition due to antiretroviral therapy (ART), which has increased life expectancy but is also associated with a higher burden of cardiovascular disease (CVD) in people living with HIV (PLHIV). Lipoprotein(a) [Lp(a)] is an independent cardiovascular risk biomarker; however, its role in PLHIV remains unclear. This study evaluated the relationship between Lp(a) and cardiovascular risk and explored its association with subclinical coronary artery disease. Methods: Cross-sectional study included PLHIV aged ≥40 years on stable ART with sustained viral suppression. Individuals with prior cardiovascular events or type 1 diabetes or long-standing type 2 diabetes (≥10 years) were excluded. Lp(a) levels and clinical data were collected. Cardiovascular risk was estimated using validated clinical scores; participants with ≥10% risk underwent coronary computed tomography angiography (CTA) to assess coronary anatomy. Results: A total of 69 patients were included (81% male; mean age 54 years). The median Lp(a) level was 23.4 nmol/L (IQR: 8.2-81.6; mean: 66.7 nmol/L); 29% had ≥75 nmol/L and 23% ≥ 105 nmol/L. A non-significant inverse association was observed between Lp(a) levels and ART duration ( Conclusions: In this cohort of virologically suppressed PLHIV, a non-significant inverse trend (

Indexed as

antiretroviral therapycardiovascular riskcoronary computed tomography angiographyHIV infectionlipoprotein(a)

Identifiers

PMID42699063
PMCPMC13542638

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