ArticleiScience2026
Dynamic interactions with neuroblasts promote oligodendrocyte progenitor migration to injured cortex.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Oligodendrocyte progenitor cells (OPCs) generated in the ventricular-subventricular zone (V-SVZ) migrate long distances to sites of brain injury to contribute to remyelination, but the mechanisms guiding their efficient recruitment remain unclear. Using a neonatal cortical injury model combined with live imaging and three-dimensional culture, we show that V-SVZ-derived OPCs migrate toward lesions by interacting with migrating neuroblasts that share the same route. Neuroblast contact significantly enhances OPC motility even in the absence of external scaffolds. High-resolution imaging reveals that these heterotypic interactions are associated with punctate adherens junctions that form and dissolve dynamically during migration. These findings uncover a previously unrecognized mechanism in which transient, dynamic adherens junctions support cooperative migration between neuronal and glial progenitors to facilitate efficient recruitment of OPCs to injured brain tissue.
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