ArticlePulmonary circulation2026
Optimized Contrast-Enhanced Micro-Computed Tomography for Simultaneous Imaging of the Ductus Arteriosus and Pulmonary Arteries During the Perinatal Transition.
Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Contrast-enhanced micro-computed tomography (micro-CT) provides high-resolution, three-dimensional visualization of small vascular structures in situ, enabling detailed analysis of morphological changes in the perinatal vasculature. The ductus arteriosus (DA) connects the aorta and pulmonary artery (PA), diverting placentally oxygenated blood away from the lungs in utero. Both DA and PA undergo rapid changes in tone with the first breath during the transition from fetal to neonatal oxygen conditions. This study aimed to optimize contrast-enhanced micro-CT protocols to enable simultaneous visualization of the DA and pulmonary vasculature during this transition in fetal rabbits. Two contrast agents, an iodine-based agent (Omnipaque, 300 mg/mL) and two forms of a barium sulphate suspension, were compared to determine which optimally opacified the DA and pulmonary circulation in fetal rabbit kits (
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