ArticleJournal of the colleges of medicine of South Africa2026
Investigating visual field measurements on perimetry and ganglion cell complex on optical coherence tomography in patients with suprasellar tumours.
Article in Journal of the colleges of medicine of South Africa, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Suprasellar tumours can cause compressive optic neuropathy with preventable visual loss. Standard automated perimetry is central to assessment but is subjective; optical coherence tomography (OCT) provides ganglion cell complex (GCC) metrics, yet structure-function relationships in chiasmal compression remain unclear. This study evaluated the relationship between GCC thickness and visual field (VF) loss (10-2 and 30-2). Methods: Prospective observational study of patients with suprasellar tumours undergoing OCT GCC imaging and Humphrey VF testing (10-2 and 30-2). Ganglion cell complex abnormality was defined as a machine-flagged red value. Visual field abnormality was defined on the pattern deviation (PD) map as a scotoma (≥ 3 adjacent points with Results: Seventeen eyes were included (mean age 50.7 years; 70.0% female). Visual field abnormality was frequent (10-2: 82.4%; 30-2: 94.1%), while GCC was abnormal in 58.8%. Mean PD was -6.84 dB (10-2) and -8.66 dB (30-2). Ganglion cell complex thickness correlated with PD at 10-2 ( Conclusion: Visual field abnormalities were common, with 30-2 classifying more eyes as abnormal despite normal GCC. Ganglion cell complex thickness showed a graded association with VF loss on both strategies, supporting OCT GCC as an adjunct for quantifying chiasmal compression-related dysfunction; however, binary OCT classification may miss milder functional deficits. Contribution: Supports combined OCT-perimetry interpretation and strategy-aware follow-up.
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