ArticleJDS communications2026
Effect of rumen-protected standardized dry grape extract supplementation on antioxidant and immune-related gene expression in leukocytes of mid-lactating Fleckvieh cows exposed to natural heat stress.
Article in JDS communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tiny but Mighty: A Low Dose of Standardized Dry Grape Extract Potentiates Antioxidant Defenses in Broiler Chickens.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress (HS) disrupts oxidative homeostasis and impairs immune function in dairy cows. In this context, plant polyphenols, when included in the diet, may modulate antioxidant defenses and immune response, including the antioxidant ability of leukocytes. This study evaluated whether supplementation with rumen-protected standardized dry grape extract (Nor-Grape BP-O; Nor-Feed) modulates antioxidant and immune-related gene expression in circulating leukocytes of mid-lactating Fleckvieh cows under natural HS. Thirty cows were randomly assigned to a control diet (CTR; n = 15) or to the same diet supplemented with 470 mg/cow per day of Nor-Grape BP-O (NG-BPO; n = 15) and monitored for 35 d during summer. Blood samples were collected at 0, 17, and 35 d for leukocyte isolation and quantitative PCR analysis. Relative gene expression was calculated using LinReg software and then transformed into ln fold change (lnFC) relative to 0 d. Data were subjected to PROC GLIMMIX procedure of SAS version 9.4 (SAS Institute). Overall, NG-BPO cows showed higher lnFC expression of glutathione peroxidase 1 (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.