Evidence map›Paper›PMID 42698783›Full record

ReviewFrontiers in cell and developmental biology2026

Exosomes-nano-messengers in tumors: capturing techniques, birth codes, and functional deciphering.

Ying-Ying Li, Ya Gao, Yan-Hong Wang, Kai-Fang Zhou, Yang Zhao, Li-Juan Zhao

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ying-Ying Li *Department of Pharmacy, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Ya Gao *State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, Henan Province, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Yan-Hong WangDepartment of Pharmacy, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Kai-Fang ZhouDepartment of Pharmacy, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Yang ZhaoDepartment of Pharmacy, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Li-Juan ZhaoState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nanoscale, membrane-bound vesicles secreted by various cell types. Owing to their cargo of parental cel-derived cellular components, exosomes show significant promise as clinical biomarkers. Meanwhile, due to their diverse origins and cargo, exosomes play a dual role in cancer, possessing the capacity to both promote and suppress tumor progression The efficient and rapid isolation and purification of exosomes are foundational for advancing their clinical applications. Additionally, a comprehensive understanding of exosome biogenesis is essential to elucidate their underlying biological functions. However, current knowledge regarding their biological characteristics and functions of action remains limited. This review delves into exosome isolation techniques, the regulatory mechanisms underlying their biogenesis and secretion, and their dual roles in cancer progression, metastasis, and tumor immunity, concluding with a discussion of the challenges and future directions in their clinical translation.

Indexed as

biogenesisexosomesimmunityisolation and identificationmetastasissecretion

Identifiers

PMID42698783
PMCPMC13541773

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.