Evidence map›Paper›PMID 42698741›Full record

ReviewFrontiers in pain research (Lausanne, Switzerland)2026

Opioid receptor agonist-antagonists in pain management: receptor specific mechanisms, dose response relationships, and clinical combination strategies.

Sining Zhao, Zhiqiang Xue, Shu Wang

Abstract readReview
In one paragraph

Review in Frontiers in pain research (Lausanne, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sining ZhaoDepartment of Anesthesiology, Benxi Central Hospital, Benxi, Liaoning, China.
Zhiqiang XueDepartment of Anesthesiology, Benxi Central Hospital, Benxi, Liaoning, China.
Shu WangDepartment of Anesthesiology, Benxi Central Hospital, Benxi, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid receptor agonist-antagonists occupy a distinctive position between high-efficacy agonists and pure antagonists and have been widely used in clinical pain management. Nevertheless, their pharmacological complexity and dose-dependent receptor interactions have led to persistent controversy regarding their analgesic efficacy, ceiling effects, and clinical performance when combined with full

Indexed as

analgesic ceiling effectdose-response relationshipintrinsic efficacymultimodal analgesiaopioid receptor agonist-antagonistsreceptor selectivity

Identifiers

PMID42698741
PMCPMC13542633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.