Evidence map›Paper›PMID 42698681›Full record

ArticleFrontiers in human neuroscience2026

Immediate excitatory effect of transcranial ultrasound intensity on the human primary motor cortex: a double-blind, sham-controlled and crossover study.

Shu Cheng, Moxian Chen, Shan Liang, Yanpin Zhao, Xiaojing Long, De Meng, Feifei Zhu, Jing Zhang, Zhongfei Bai, Lijuan Ao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shu Cheng *School of Rehabilitation, Kunming Medical University, Kunming, China.
Moxian Chen *School of Rehabilitation, Kunming Medical University, Kunming, China.
Shan Liang *Department of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Yanpin ZhaoDepartment of Pediatric Rehabilitation Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Xiaojing LongShenzhen Institute of Advance Technology, Chinese Academy of Sciences, Shenzhen, China.
De MengShenzhen Institute of Advance Technology, Chinese Academy of Sciences, Shenzhen, China.
Feifei ZhuDepartment of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Jing ZhangDepartment of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Zhongfei BaiDepartment of Neurology and Neurological Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Lijuan AoSchool of Rehabilitation, Kunming Medical University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To systematically characterize the intensity-dependent effects of low-intensity transcranial ultrasound stimulation (TUS) on excitability in the human primary motor cortex (M1) and to identify an effective intensity threshold for inducing immediate excitatory changes. Methods: In a randomized, double-blind, sham-controlled crossover design, twenty-five healthy right-handed adults (mean age, 24.0 ± 3.3 years) received 20 min of 500 kHz TUS to their M1 hotspot. Five sessions were conducted, each employing a different spatial peak pulse average intensity (ISPPA: 3, 6, 9, or 12 W/cm Results: A clear intensity-dependent effect was observed. Only sonication at 12 W/cm Conclusion: Our findings demonstrate that TUS modulates human M1 excitability in a selective and intensity-dependent manner, identifying an ISPPA of 12 W/cm Clinical trial registration: Identifier, ChiCTR2600125507.

Indexed as

focused ultrasoundmotor cortexneuroplasticityspatial peak pulse average intensitytranscranial magnetic stimulation

Identifiers

PMID42698681
PMCPMC13541700

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.