Evidence map›Paper›PMID 42698668›Full record

ArticleMolecular therapy. Oncology2026

Ultrasound controllable and antigen-independent killing via

Linshan Zhu, Jiaxin Cui, Chi-Wei Man, Anthony Mouchawar, Xi Yu, Yixuan Huang, Yiqian Wu, Tianze Guo, Hongquan Xu, Longwei Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Linshan ZhuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.
Jiaxin CuiAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.
Chi-Wei ManDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Anthony MouchawarDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.
Xi YuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.
Yixuan HuangAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.
Yiqian WuNational Biomedical Imaging Center, College of Future Technology, Peking University, Beijing 100871, China.
Tianze GuoAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.
Hongquan XuDepartment of Statistics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Longwei LiuAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.
Yingxiao WangAlfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, Los Angeles, CA 90089, USA.

Funding

Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under FlowsR01HL121365 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIEN, SHU, WANG, YINGXIAO · 2014 to 2025
$7.5M
Ultrasensitive kinase biosensors for multiplex imaging of coordinated spatiotemporal signaling in cancer-immune interactionsR01CA262815 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yingxiao Wang, Jin Zhang · 2022 to 2026
$3.3M
Single Cell Tracking of 3D Epigenetic Landscape Evolution During Embryonic DevelopmentR01HD107206 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yingxiao Wang, Sheng Zhong · 2022 to 2026
$3.2M
Acoustothermogenetics for Cell EngineeringR35GM140929 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, YINGXIAO · 2021 to 2025
$2.9M
Ultrasound-controlled remote activation of CAR T cells for localized tumor immunotherapyR01EB029122 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, YINGXIAO · 2020 to 2023
$1.7M
Development of single fluorophore biosensors for multiplex imaging of CAR T SignalingK01EB035649 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Longwei Liu · 2024 to 2026
$455k
NCI NIH HHS R01 CA262815NHLBI NIH HHS R01 HL121365NIBIB NIH HHS K01 EB035649NIBIB NIH HHS R01 EB029122NICHD NIH HHS R01 HD107206NIGMS NIH HHS R35 GM140929
6 · The paper itself

Abstract

Clinical efficacy of chimeric antigen receptor (CAR) T cell therapy is limited by tumor antigen escape and heterogeneity, leading to cancer relapse. To address this limitation, we developed a focused ultrasound (FUS) controllable and

Indexed as

acoustogeneticsantigen escapeCAR T cellMT: Regular Issuetumor heterogeneity

Identifiers

PMID42698668
PMCPMC13542499

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.