ArticlePlastic and reconstructive surgery. Global open2026
Pilot Study: Dermal Regenerative Templates for Complex Wound Management: Adding a New Rung to the Reconstructive Ladder.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: Skin grafting with dermal regenerative templates (DRTs) has emerged as an effective option within the reconstructive ladder for coverage of full-thickness wounds. This approach reduces the need for flap reconstruction, shortens hospitalization, and minimizes wound-related morbidity while improving functional and aesthetic outcomes. We present a case series of patients treated with a novel hydrogel-based DRT (hDRT) composed of type I bovine collagen microspheres embedded within a lower density type I bovine collagen hydrogel. We describe outcomes of wounds treated using this template. Methods: A retrospective chart review of patients who underwent definitive coverage of full-thickness skin defects with an hDRT was performed. Results: Thirteen defects in 10 patients underwent reconstruction. Defect locations included the face, scalp, and extremities. Wound etiologies included oncological, traumatic, and donor-site defects. Exposed tissues included tendon, bone, nerve, and galea. Defect size ranged from 2 to 100 cm Conclusions: This novel dual-density hDRT demonstrated favorable results in wound reconstruction as a result of accelerated vascularization leading to reduced treatment time and patient morbidity. Larger studies are required to compare the efficacy with other products on the market.
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