ArticleCureus2026
Recurrent Cholestatic Jaundice in a Young Indian Adult: A Clinical Diagnosis of Benign Recurrent Intrahepatic Cholestasis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Benign recurrent intrahepatic cholestasis (BRIC) is a rare hereditary cholestatic disorder characterized by recurrent episodes of intermittent cholestatic jaundice and pruritus without causing detectable lasting liver damage. Owing to its rarity and the absence of pathognomonic findings, the diagnosis is often delayed and requires exclusion of more common causes of recurrent cholestasis. We report the case of a 25-year-old male who presented with recurrent episodes of severe cholestatic jaundice with intense generalized pruritus. The patient clinically and biochemically recovered after treatment with ursodeoxycholic acid (UDCA). Based on the characteristic recurrence pattern, severe pruritus, normal serum gamma-glutamyl transferase (GGT) levels during the current episode, normal hepatobiliary imaging, complete clinical recovery between attacks, and exclusion of alternative causes of cholestasis, a presumptive clinical diagnosis of BRIC was made. Although genetic confirmation was not done, the clinical features were most consistent with BRIC.
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