Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis.

Zhiqing Zhou, Lingling Zhao, Lei Chen, Xuanxiang Zhao, Xinwei Li, Xuying Luo, Bin Zhang, Jianyin Miao, Feitong Liu

Abstract read

In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiqing ZhouOverseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, Guangzhou, China.

Lingling ZhaoChina Research and Innovation Center, H&H Research, H&H Group, Guangzhou, China.

Lei ChenChina Research and Innovation Center, H&H Research, H&H Group, Guangzhou, China.

Xuanxiang ZhaoGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, China.

Xinwei LiGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, China.

Xuying LuoSchool of Food Science and Engineering, South China University of Technology, Guangzhou, China.

Bin ZhangOverseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, Guangzhou, China.

Jianyin MiaoGuangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, China.

Feitong LiuOverseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Skin aging involves intrinsic chronological aging and extrinsic photoaging, characterized by impaired barrier function, extracellular matrix (ECM) degradation, and chronic inflammation. Methods: This study evaluated anti-aging efficacy and mechanisms of ergothioneine (EGT), collagen peptides (CP) and sodium hyaluronate (NaHA) using an Results: Conclusion: These findings demonstrate that TC exerts multifaceted anti-aging effects by targeting oxidative stress, inflammatory pathways, and ECM homeostasis, providing a scientific basis for the development of novel oral nutricosmetics for facial skin anti-aging.

Indexed as

anti-agingcollagen peptidesergothioneineextracellular matrix homeostasisfacial skin agingoral nutricosmeticoxidative stresssodium hyaluronate

Identifiers

PMID42698538

DOI10.3389/fnut.2026.1888269

PMCPMC13541516

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.