ArticleFrontiers in cell and developmental biology2026
Sufentanil attenuates LPS-induced acute lung injury by suppressing ferroptosis and maintaining GPX4 protein abundance.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Acute lung injury (ALI) is a severe inflammatory syndrome characterized by disruption of the alveolar-capillary barrier, pulmonary edema, and impaired gas exchange. Ferroptosis has emerged as an important contributor to ALI pathogenesis, but the mechanisms associated with reduced glutathione peroxidase 4 (GPX4) protein abundance during lung injury remain incompletely understood. Methods: This study investigated the protective effects of sufentanil pretreatment against lipopolysaccharide (LPS)-induced ALI and examined whether these effects were associated with ferroptosis suppression and maintenance of GPX4 protein abundance. A mouse model of LPS-induced ALI and LPS-stimulated A549 cells were used to evaluate the effects of sufentanil Results: Sufentanil pretreatment alleviated LPS-induced lung injury, reduced inflammatory responses, and attenuated ferroptosis-associated alterations Discussions: These findings support a preconditioning effect of sufentanil against LPS-induced ALI, associated with ferroptosis suppression, maintenance of GPX4 protein abundance, and possible CMA-related lysosomal involvement.
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