ArticleFrontiers in nutrition2026
Effects of peanut consumption on task-related brain activation, cognition and neuroinflammation in older adults with memory complaints: a randomized controlled trial.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05532007 (Effects of Peanut Intake on Task-related Brain Activation and Cognitive Functions in Older Adults With Memory Complaints), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Effects of Peanut Intake on Task-related Brain Activation and Cognitive Functions in Older Adults With Memory Complaints: A Randomized Controlled Study
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: Peanuts are rich in unsaturated fats, antioxidants like polyphenols, and other bioactive compounds that may reduce neuroinflammation and support cognitive health. Although limited evidence suggests potential cognitive benefits of peanut intake, none have explored these effects in older adults at risk for cognitive decline or assessed brain activity using functional magnetic resonance imaging (fMRI). This study explored the effects of daily peanut consumption on task-related brain activation, cognition, and neuroinflammation biomarkers in older adults with cardiovascular disease (CVD) risk factors and memory complaints. Methods: In this 12-week, controlled, parallel-design, open-label randomized trial registered at ClinicalTrials.gov (NCT05532007), 30 overweight or obese older adults with memory complaints and CVD risk factors were randomized to a peanut group (PG), which consumed 42-86 g/d of peanuts and peanut butter, or a control group (CG), which abstained from peanuts. The final analyzed sample included 27 participants (PG, Results: No significant between-group differences were observed in task-related brain activation or cognitive performance. Although some biomarker outcomes were nominally significant in unadjusted analyses, no Time × Group interactions remained significant after adjustment and correction for multiple comparisons. Conclusion: In overweight or obese older adults with elevated CVD risk and memory complaints, a 12-week peanut intervention did not produce significant changes in cognition or task-related activation of the brain. Future studies with larger sample sizes, longer intervention durations, and greater statistical power are needed to determine whether peanut consumption may influence neurocognitive trajectories and to further investigate the role of inflammatory and oxidative stress mechanisms in these relationships.
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