ArticleFrontiers in medicine2026
Clinical characteristics and factors associated with in-hospital mortality in patients with
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: This single-center retrospective cohort study included 458 hospitalized patients with confirmed Results: Overall in-hospital mortality was 11.8% (54/458). Compared with survivors, non-survivors were older, had a higher Charlson Comorbidity Index (CCI), and more frequently presented with severe clinical features, including septic shock, mechanical ventilation, central venous catheterization, and elevated inflammatory markers. In the multivariable model, older age and higher CCI remained independently associated with mortality, whereas mechanical ventilation showed a strong but statistically non-significant association. Prior carbapenem exposure was common, but mortality was comparable between carbapenem-exposed and unexposed patients. The appropriateness of initial empirical antimicrobial therapy was not independently associated with survival after adjustment for baseline and severity-related factors. Antimicrobial susceptibility testing showed high Conclusions: In this cohort of patients with
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