Evidence map›Paper›PMID 42697964›Full record

ReviewThe EMBO journal2026

Dynamic control of cell state transitions during tissue morphogenesis.

Joana E Saraiva, Sandra Edwards-Jorquera, Elias H Barriga

Abstract readReview
PubMed Publisher
In one paragraph

Review in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joana E Saraiva *Biophysical Mechanisms of Morphogenesis Lab, Cluster of Excellence Physics of Life (PoL), TU Dresden, Dresden, Germany.
Sandra Edwards-Jorquera *Biophysical Mechanisms of Morphogenesis Lab, Cluster of Excellence Physics of Life (PoL), TU Dresden, Dresden, Germany.
Elias H BarrigaBiophysical Mechanisms of Morphogenesis Lab, Cluster of Excellence Physics of Life (PoL), TU Dresden, Dresden, Germany. elias.barriga@tu-dresden.de.ORCID http://orcid.org/0000-0003-2912-3613

Funding

Deutsche Forschungsgemeinschaft (DFG) EXC 2068,390729961EC | European Research Council (ERC) 950254European Molecular Biology Organization (EMBO) 5248Grant from HFSP Ref.-No: RGP003/2026) under the DOI number https://doi.org/10.52044/HFSP.RGP0032026.pc.gr.243775Human Frontier Science Program (HFSP) RGP003/2026MEC | Fundação para a Ciência e a Tecnologia (FCT) (UI/BD/152251/2021)Wellcome Trust (WT) 304976/Z/23/Z
6 · The paper itself

Abstract

Morphogenesis, the process by which cells, tissues, and organs acquire and maintain their form, is essential for embryogenesis, regeneration, and disease progression. During morphogenesis, cells within tissues dynamically interact with biophysical and biochemical signals from their environment by modifying their shape, gene expression, and function. These modifications often lead to transitions between cell states, and with that, to the establishment of functional programs that will in turn define embryonic stages or tissue states. Here, we discuss how the interplay of gene expression programs, chromatin modifications, and biophysical factors from the microenvironment contributes to the robust coordination of morphogenesis by allowing cells within tissues to dynamically transit across functional stages.

Identifiers

PMID42697964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.