Evidence map›Paper›PMID 42697173›Full record

ArticleThe journal of nutrition, health & aging2026

Seafood and polyunsaturated fatty acid intake and age-related hearing loss: a cross-sectional study conducted in Japan.

Jun Suzuki, Hiroki Tozuka, Hiyori Takahashi, Ikuko N Motoike, Miyuki Sakurai, Yuta Kobayashi, Gosuke Watarai, Mana Kogure, Tetsuaki Kawase, Yohei Honkura and 9 more

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Article in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jun SuzukiDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address: jun.suzuki.c2@tohoku.ac.jp.
Hiroki TozukaDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address: bomb1079@outlook.jp.
Hiyori TakahashiDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address: pi_oyadomari@yahoo.co.jp.
Ikuko N MotoikeTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. Electronic address: ikuko.motoike.b8@tohoku.ac.jp.
Miyuki SakuraiTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. Electronic address: miyuki.sakurai.e2@tohoku.ac.jp.
Yuta KobayashiDepartment of Otolaryngology-Head and Neck Surgery, JCHO Sendai Hospital, Sendai, Miyagi, Japan. Electronic address: yuta.kobayashi.med@gmail.com.
Gosuke WataraiDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address: gw.no.13@hotmail.co.jp.
Mana KogureTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan; Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. Electronic address: mana.kogure.e7@tohoku.ac.jp.
Tetsuaki KawaseDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan; Laboratory of Rehabilitative Auditory Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, Miyagi, Japan. Electronic address: tetsuaki.kawase.e8@tohoku.ac.jp.
Yohei HonkuraDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address: yohei.honkura.d5@tohoku.ac.jp.
Ryoukichi IkedaDepartment of Otolaryngology, Head and Neck Surgery, Iwate Medical University School of Medicine, Yahaba, Iwate, Japan. Electronic address: ryoukich@hotmail.com.
Kengo KinoshitaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Miyagi, Japan; Department of Applied Information Sciences, Graduate School of Information Sciences, Tohoku University, Sendai, Miyagi, Japan. Electronic address: kengo@tohoku.ac.jp.
Naoki NakayaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan; Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. Electronic address: naoki.nakaya.c2@tohoku.ac.jp.
Taku ObaraTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan; Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. Electronic address: taku.obara.a5@tohoku.ac.jp.
Atsushi HozawaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan; Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. Electronic address: atsushi.hozawa.a6@tohoku.ac.jp.
Shinichi KuriyamaTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan; International Research Institute of Disaster Science, Disaster Medical Science Division, Disaster-related Public Health, Tohoku University, Sendai, Miyagi, Japan. Electronic address: shinichi.kuriyama.e6@tohoku.ac.jp.
Nobuo FuseTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan; Department of Integrative Genomics, Tohoku University, Sendai, Miyagi, Japan. Electronic address: nobuo.fuse.b6@tohoku.ac.jp.
Masayuki YamamotoTohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. Electronic address: masayuki.yamamoto.c7@tohoku.ac.jp.
Yukio KatoriDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. Electronic address: yukio.katori.d1@tohoku.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related hearing loss (ARHL) is a common condition associated with dementia, social isolation, and reduced quality of life. N-3 polyunsaturated fatty acids (N-3 PUFAs), mainly derived from seafood, have been hypothesized to protect against ARHL through anti-inflammatory and antioxidant effects. However, evidence remains inconsistent. This cross-sectional study examined the association of seafood and dietary fatty acid intakes with ARHL in a Japanese population with high seafood consumption.

methodsA total of 13,908 adults aged 50-79 years from the Tohoku Medical Megabank Project Cohort Study were included. Hearing thresholds were measured by pure-tone audiometry at 500, 1,000, 2,000, and 4,000 Hz. Dietary intake was assessed using a validated food frequency questionnaire. Seafood, N-3 PUFA, and saturated fatty acid (SFA) intakes were categorized into quartiles. Multivariable linear regression was used to estimate adjusted mean differences in hearing thresholds.

resultsIn men, higher SFA intake was significantly associated with lower hearing thresholds at 1,000 Hz (Q4 vs. Q1: β = -2.23 dB HL, 95% CI: -3.437 to -1.023) and for pure-tone average (β = -1.704 dB HL; 95% CI, -2.872 to -0.536). Seafood and N-3 PUFA intakes were not significantly associated with hearing thresholds. In women, no significant associations were observed.

conclusionIn this population with high seafood consumption, seafood and N-3 PUFA intakes were not associated with hearing thresholds. Low SFA intake may be associated with higher hearing thresholds in Japanese men, suggesting that the relationship between dietary fatty acids and ARHL may be complex and may differ by sex.

Indexed as

Age-related hearing lossDietary intakeFatty acidJapaneseSeafood

Identifiers

PMID42697173
PMCPMC13571989

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