Evidence map›Paper›PMID 42696960›Full record

ArticlePlacenta2026

Bridging cotyledon histopathology and perfusion in healthy primate pregnancy.

Logan T Keding, Ruo-Yu Liu, Taylor J Keding, Jessica Vazquez, Crystal G Bockoven, Dinesh M Shah, Thaddeus G Golos, Oliver Wieben, Aleksandar K Stanic

Abstract read
PubMed Publisher
In one paragraph

Article in Placenta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Logan T KedingDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, 202 South Park St, Madison, WI, 53715, USA; Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1223 Capitol Ct, Madison, WI, 53715, USA. Electronic address: LKeding@wisc.edu.
Ruo-Yu LiuDepartment of Medical Physics, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI, 53705, USA.
Taylor J KedingDepartment of Psychology, Yale University, 100 College St, New Haven, CT, 06510, USA; Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT, 06520, USA.
Jessica VazquezDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, 202 South Park St, Madison, WI, 53715, USA; Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1223 Capitol Ct, Madison, WI, 53715, USA.
Crystal G BockovenDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 1685 Highland Ave, Madison, WI, 53705, USA.
Dinesh M ShahDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, 202 South Park St, Madison, WI, 53715, USA.
Thaddeus G GolosDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, 202 South Park St, Madison, WI, 53715, USA; Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1223 Capitol Ct, Madison, WI, 53715, USA; Department of Comparative Biosciences, University of Wisconsin-Madison, 2015 Linden Dr, Madison, WI, 53706, USA.
Oliver WiebenDepartment of Medical Physics, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI, 53705, USA; Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA.
Aleksandar K StanicDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, 202 South Park St, Madison, WI, 53715, USA.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Magnetic resonance imaging of the antecedents of fetal growth restriction at the primate maternal-fetal interfaceR01HD103443 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SHAH, DINESH MANILAL, WIEBEN, OLIVER · 2020 to 2024
$3.2M
Coagulation-inflammation crosstalk in placental abruptionR01HL163623 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Rashmi Sood · 2023 to 2026
$2.4M
Integrated Program in Endocrinology Translational Postdoctoral Training ProgramT32HD101384 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI IAN M. BIRD, Jon E Levine · 2021 to 2026
$2.0M
Sterile Inflammation at the Maternal-Fetal Interface and Fetal Immune Programming in a Non-Human Primate ModelK01AI182448 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Jessica Vazquez · 2024 to 2026
$658k
Gestationally driven trafficking of decidual lymphocytes assessed by serial intravascular stainingR21AI175753 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI STANIC-KOSTIC, ALEKSANDAR · 2023 to 2024
$428k
NHLBI NIH HHS R01 HL163623NIAID NIH HHS K01 AI182448NIAID NIH HHS R21 AI175753NICHD NIH HHS L70 HD119811NICHD NIH HHS R01 HD103443NICHD NIH HHS T32 HD101384NIH HHS P51 OD011106
6 · The paper itself

Abstract

introductionHealthy and diseased placentae alike often display some degree of histopathology. However, quantitative techniques to characterize common placental lesions and their relationship to local maternal hemodynamics in healthy pregnancy are currently limited.

methodsSeven pregnant macaques with healthy fetoplacental biometrics were recruited for study. Placentae were imaged by MRI at three time points across mid-to late-gestation to quantify volume, blood flow, and perfusion of maternal blood across pregnancy. Near term, we collected placental cotyledons, imaged hematoxylin/eosin-stained slides, then annotated major histopathological features (sub-tissues, intervillous gaps, fibrin deposition, villous agglutination, inflammatory agglutination, and stromal mineralization) within each cotyledon. Histopathological lesions were assessed in relation to each other and MRI-based perfusion metrics, in a cotyledon-specific manner. Parallel analyses were performed to investigate both basic (Spearman correlation) and animal variance-conditioned (dimensionality-reduction) relationships.

resultsDimensionality reduction analysis revealed maternal vascular malperfusion-associated histopathology as the main contributor to dataset variance and was positively associated with increased maternal blood perfusion across gestation. Cotyledons with increased stromal mineralization demonstrated low blood perfusion across pregnancy, alongside changes potentially indicative of maternal compensation. Additionally, histopathology associated with healthy placental function demonstrated low cotyledon blood flow at all timepoints.

conclusionsWe revealed several relationships connecting histopathology and perfusion in the healthy pregnancy, such as maternal vascular malperfusion-associated lesions increasing with increased maternal blood perfusion - all accomplished at the smallest functional unit of the placenta. This methodological framework embeds pathologist-refined morphological expertise into a quantitative, spatially resolved format that can better ground unsupervised computational approaches to placental analysis.

Indexed as

Blood perfusionCotyledonHistopathological annotationHistopathologyMaternal compensationRhesus macaque

Identifiers

PMID42696960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.