In one paragraphArticle in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
28 authors.
Mathieu DeygasInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0003-3417-8133 Mathilde BernardInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0002-1158-7623 Pierre NivoitInstitut Pasteur, Université Paris Cité, INSERM UMR1225, Pathogenesis of vascular infections, Paris, France.ORCID 0000-0002-4893-6348 Alexandre DeslysLeukomotion Lab, Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.ORCID 0009-0001-3241-035X Theresa JakuszeitInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0003-3848-7486 Damien CuvelierSorbonne University, Institut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0001-9875-1467 Moira Garcia-GomezLeukomotion Lab, Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.ORCID 0009-0000-2221-9423 Lucie BarbierInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0001-7102-3566 Li WangInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0001-9646-4536 Emmanuel TejerinaLeukomotion Lab, Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.ORCID 0000-0001-8673-1493 Oumaima BaazizLeukomotion Lab, Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.ORCID 0009-0000-2958-0879 Emmanuel TerriacInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0002-8769-242X Rafaele AttiaInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0009-0005-1588-814X Anna KniazevaInstitut Curie, INSERM U932, PSL Research University, Paris, France.
Serge GarbayLeukomotion Lab, Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Paris, France.ORCID 0000-0002-1396-8438 Marina Ortega-ZaperoLamImSys Laboratory, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0002-7358-3265 Angela SaezLamImSys Laboratory, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0002-9189-4737 Raquel Gomez-BrisLamImSys Laboratory, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0001-6665-7732 Jose M Gonzalez-GranadoLamImSys Laboratory, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.ORCID 0000-0002-1177-869X Guillaume DuménilInstitut Pasteur, Université Paris Cité, INSERM UMR1225, Pathogenesis of vascular infections, Paris, France.ORCID 0000-0001-9174-9110 Matthieu PielInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0002-2848-177X Pablo VargasInstitut Curie and Institut Pierre-Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.ORCID 0000-0002-6475-494X Funding
Cellular Decision Making Diversity SupplementR35GM118167 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Orion D Weiner · 2016 to 2026
$10.3MMembrane tension as a long-range integrator of cell physiologyK99GM154115 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DE BELLY, HENRY · 2024 to 2025
$239kNIGMS NIH HHS K99 GM154115NIGMS NIH HHS R35 GM118167
6 · The paper itselfAbstract
To reach inflamed tissues, neutrophils must traverse capillaries as narrow as 2 micrometers. However, how they do so without compromising blood flow or capillary function has remained unclear. By combining intravital live-cell imaging with biomimetic microdevices, we show that neutrophils maintain migration speed in capillaries across increasing levels of confinement. This behavior was not shared by other leukocytes and was independent of nuclear properties. Instead, confinement rapidly engaged Rho-dependent actomyosin contractility at the cell rear, thereby offsetting the increased mechanical resistance imposed by confinement. Disrupting this adaptive response caused neutrophil jamming and eventual occlusion of confined capillary-like networks. These findings identify a neutrophil-intrinsic mechanism that couples capillary confinement to rapid migratory adaptation, helping preserve vascular patency and potentially limiting tissue dysfunction during inflammation.
Indexed as
CapillariesCell MovementNeutrophilsActomyosinAnimalsHumansActomyosin
Identifiers
PMID42696606
PMCPMC13676789
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