Evidence map›Paper›PMID 42696594›Full record

ArticleScience advances2026

Branched-chain amino acid assimilation enables mixotrophy of ammonia-oxidizing archaeal sponge symbionts.

Bettina Glasl, Katharina Kitzinger, Heidi M Luter, Anton Legin, Stefan Schuster, Erika Salas, Nathalie Heldwein, Katarina Damjanovic, Marie Rutsch, Bram Vekeman and 7 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bettina GlaslDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-6812-868X
Katharina KitzingerDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0001-7382-7103
Heidi M LuterAustralian Institute of Marine Science, Townsville, Australia.ORCID 0000-0001-7810-7076
Anton LeginDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-4088-5769
Stefan SchusterDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.
Erika SalasDivision of Terrestrial Ecosystem Research, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-9917-8866
Nathalie HeldweinDivision of Terrestrial Ecosystem Research, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0009-0009-6138-3782
Katarina DamjanovicAustralian Institute of Marine Science, Townsville, Australia.ORCID 0000-0002-3893-4381
Marie RutschDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0009-0006-4154-7119
Bram VekemanDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.
Nicole M J GeerlingsDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0003-2056-5650
Petra PjevacDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0001-7344-302X
Joana SénecaDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0003-3951-3674
Margarete WatzkaDivision of Terrestrial Ecosystem Research, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.
Wolfgang WanekDivision of Terrestrial Ecosystem Research, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0003-2178-8258
Daan R SpethDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-2361-5935
Michael WagnerDivision of Microbial Ecology, Centre for Microbiology and Environmental Systems Science, University of Vienna, Vienna, Austria.ORCID 0000-0002-9778-7684

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine sponges and ammonia-oxidizing archaea (AOA) represent one of the earliest animal-microbe symbioses. AOA are considered metabolically constrained chemolithoautotrophs that remove nitrogenous waste within the sponge holobiont. Here, we expand this view by demonstrating that symbiotic AOA assimilate branched-chain amino acids (BCAA) as additional carbon and nitrogen sources. By combining stable isotope probing with fluorescence and chemical imaging, we trace the assimilation of

Indexed as

Amino Acids, Branched-ChainAmmoniaArchaeaPoriferaSymbiosisAnimalsOxidation-ReductionAmino Acids, Branched-ChainAmmonia

Identifiers

PMID42696594
PMCPMC13552627

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.