In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Ruiming ZhaoDepartments of Pediatrics and Physiology & Biophysics, School of Medicine and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-1329-2773 Maha NayakDepartments of Pediatrics and Physiology & Biophysics, School of Medicine and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-7404-6309 Rong ShenDepartment of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-4332-4518 Hui DaiDepartments of Pediatrics and Physiology & Biophysics, School of Medicine and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0002-0440-7815 Punyanuch HuaDepartments of Pediatrics and Physiology & Biophysics, School of Medicine and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-8821-3729 Eduardo PerozoDepartment of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-7132-2793 Steve A N GoldsteinDepartments of Pediatrics and Physiology & Biophysics, School of Medicine and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Susan and Henry Samueli College of Health Sciences, University of California, Irvine, CA 92697, USA.ORCID 0000-0001-5207-5061 Funding
hHv1 channels in neutrophils and the innate immune inflammatory responseR01HL159711 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDSTEIN, STEVE A N, ZHAO, RUIMING · 2022 to 2025
$2.4MStructural Basis of Coupling and Dynamics in K+ ChannelsR01GM150272 · NIGMS · UNIVERSITY OF CHICAGO · PI Eduardo A Perozo · 2023 to 2026
$2.2MIdentification of botanical hHv1 channel blockers as analgesics for neuropathic painR33AT012544 · NCCIH · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDSTEIN, STEVE A N, WU, LONG-JUN · 2024 to 2025
$873kIdentification of botanical hHv1 channel blockers as analgesics for neuropathic painR61AT012544 · NCCIH · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDSTEIN, STEVE A N, ZHAO, RUIMING · 2023 to 2023
$256kNCCIH NIH HHS R33 AT012544NCCIH NIH HHS R61 AT012544NHLBI NIH HHS R01 HL159711NIGMS NIH HHS R01 GM150272
6 · The paper itselfAbstract
Most voltage-gated potassium (Kv) channels are inhibited by peptide neurotoxins that occlude the pore with a positively-charged lysine. Kv1.5 repels these toxins electrostatically via four arginines (R487), one on each pore-forming subunit. Here, we describe chimera toxin (CmTx), a potent and selective blocker that prefers the slow-inactivated Kv1.5 conformation promoted by rapid firing and acidosis (
Indexed as
Kv1.5 Potassium ChannelPeptidesPotassium Channel BlockersAmino Acid SequenceAnimalsHumansModels, MolecularStatic ElectricityKv1.5 Potassium ChannelPeptidesPotassium Channel Blockers
Identifiers
PMID42696590
PMCPMC13544209
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