Evidence map›Paper›PMID 42696577›Full record

ArticleScience advances2026

Discovery of CDK8/19 inhibitors as lead compounds for IL-6-dependent lymphoma enabled by the formal synthesis of cortistatin A.

Wenjun Wang, Nan Zhang, Baicheng Chen, Zijing Chen, Guihua Zeng, Tuoping Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenjun WangInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China.ORCID 0000-0002-6803-0762
Nan ZhangPeking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.ORCID 0009-0001-5735-3945
Baicheng ChenKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Zijing ChenKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Guihua ZengInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China.ORCID 0000-0001-9211-2138
Tuoping LuoInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518055, China.ORCID 0000-0003-2156-3198

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A formal synthesis of cortistatin A, a marine-derived steroidal alkaloid with potent anti-angiogenic and antileukemic activities, was achieved via a unique synthetic strategy that leveraged a late-stage SmI

Indexed as

Antineoplastic AgentsCyclin-Dependent Kinase 8Cyclin-Dependent KinasesInterleukin-6Lymphoma, Large B-Cell, DiffuseProtein Kinase InhibitorsAnimalsApoptosisCell Line, TumorCell ProliferationHumansMicePolycyclic CompoundsSignal TransductionSTAT3 Transcription FactorXenograft Model Antitumor AssaysAntineoplastic AgentsCDK19 protein, humanCDK8 protein, humancortistatin ACyclin-Dependent Kinase 8Cyclin-Dependent KinasesInterleukin-6Polycyclic CompoundsProtein Kinase InhibitorsSTAT3 Transcription Factor

Identifiers

PMID42696577
PMCPMC13544219

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.