Evidence map›Paper›PMID 42696452›Full record

ArticleCell reports2026

The regulation of COX-2, ABCA1, and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis.

Elizabeth J Hennessy, Takae Tanosaki, Ronan Lordan, Soon Yew Tang, Vladimir V Shuvaev, Soumita Ghosh, Ujjalkumar S Das, Robin Joshi, Hu Meng, John N Snouwaert and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elizabeth J HennessyInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Takae TanosakiInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ronan LordanInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Soon Yew TangInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vladimir V ShuvaevDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Soumita GhoshInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ujjalkumar S DasInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robin JoshiInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hu MengInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
John N SnouwaertDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Hanna WinterInstitute of Molecular Vascular Medicine, University Hospital rechts der Isar, Technical University Munich, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Lars MaegdefesselInstitute of Molecular Vascular Medicine, University Hospital rechts der Isar, Technical University Munich, Munich, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Beverly H KollerDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Garret A FitzGeraldInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: garret@upenn.edu.

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
NCATS NIH HHS UL1 TR001878
6 · The paper itself

Abstract

Cyclooxygenase-2 (COX-2) plays a central role in inflammation, but its inhibition is associated with increased cardiovascular risk. Here, we investigate the COX-2 antisense long non-coding RNA (lncRNA) PTGS2 antisense complex-mediated expression regulator RNA (PACERR) and its potential role in pathways linking inflammation and cholesterol homeostasis. PACERR expression is induced by high-density lipoprotein (HDL) and lipopolysaccharide (LPS) and is associated with changes in COX-2, ABCA1, and ABCG1 expression in vascular (smooth muscle and endothelial) and immune cells (macrophages). PACERR interacts with regulatory proteins p300, hnRNPL, and IκBζ, and its perturbation alters their association with target loci. Silencing PACERR enhances HDL-induced cholesterol efflux and modifies COX-2 expression and prostaglandin production. PACERR is also associated with regulatory elements near PLA2G4A (cPLA

Indexed as

ATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CholesterolCyclooxygenase 2HomeostasisInflammationRNA, Long NoncodingAnimalsGene Expression RegulationHumansLipopolysaccharidesMacrophagesMiceABCA1 protein, humanABCG1 protein, humanATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CholesterolCyclooxygenase 2LipopolysaccharidesRNA, Long NoncodingcholesterolchromatinCP: metabolismCP: molecular biologyinflammationlong non-coding RNAprostaglandins

Identifiers

PMID42696452
PMCPMC13679678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.