Evidence map›Paper›PMID 42696447›Full record

ArticleThe Journal of frailty & aging2026

Higher cystatin C, but not creatinine, predicts frailty risk in individuals with normal kidney function.

Fan Zhang, Yue Xing, Yan Bai, Liuyan Huang, Yifei Zhong

Abstract read
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In one paragraph

Article in The Journal of frailty & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fan ZhangDepartment of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yue XingDepartment of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yan BaiDepartment of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Liuyan HuangDepartment of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yifei ZhongDepartment of Nephrology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: sh_zhongyifei@shutcm.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study investigates the associations of creatinine and cystatin C with frailty risk in individuals with normal kidney function, using data from the Health and Retirement Study (HRS) and the China Health and Retirement Longitudinal Study (CHARLS).

methodsWe used CKD-EPI to estimate glomerular filtration rate based on serum creatinine (eGFR

resultsCreatinine levels showed no significant association with frailty risk in individuals with normal kidney function across both cohorts. In contrast, cystatin C levels were consistently and significantly associated with an increased risk of frailty in individuals with normal eGFR

conclusionsHigher cystatin C levels, but not creatinine levels, were significantly associated with an increased risk of frailty among individuals with normal kidney function, suggesting that cystatin C may be a useful biomarker for early identification of frailty risk.

Indexed as

CreatinineCystatin CEstimate glomerular filtration rateFrailty

Identifiers

PMID42696447
PMCPMC13571487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.