ReviewJornal brasileiro de nefrologia
Analysis of novel predictors of acute kidney injury after non-cardiac surgery: an integrative review.
Review in Jornal brasileiro de nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute kidney injury (AKI) is a common postoperative complication (postoperative AKI, [PO-AKI]), occurring in up to 35% of non-cardiac surgery. Some biomarkers have shown value in early identification but are underused in clinical practice due to their high cost. The SPARK score and the hemoglobin-to-red cell distribution width ratio (Hb/RDW) have emerged as accessible alternatives for predicting PO-AKI.
objectiveTo evaluate studies on SPARK predictors and hematological biomarkers for risk stratification of PO-AKI in non-cardiac surgery.
methodsAn integrative review was conducted across four databases (PubMed/MEDLINE, LILACS, Embase, and Web of Science), covering publications between 2019 and 2025 in Portuguese and English. Studies including adults undergoing non-cardiac surgery were included. The selection process was documented using a PRISMA 2020 flow diagram.
resultsSix studies were included. The SPARK score showed an AUC ranging from 0.69 to 0.81 in external validations, with superior performance in modified models for specific populations. The Hb/RDW index demonstrated good accuracy (AUC 0.714; sensitivity 72.7%; specificity 70.8%) in elderly orthopedic patients, with lower values associated with increased risk of PO-AKI. DISCUSSION: The effectiveness of SPARK depends on the population profile, highlighting the importance of external validation and contextual adjustments. Hb, RDW, and the Hb/RDW ratio appear to be promising tools to complement SPARK.
conclusionThe application of SPARK may be limited in different contexts. Simple biomarkers such as Hb, RDW, and Hb/RDW show good predictive potential and may improve the early identification of patients at risk for PO-AKI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.