Evidence map›Paper›PMID 42696105›Full record

ArticleNeuroscience bulletin2026

Identification of Age-Associated Upstream Regulators to Promote Neuronal Resilience in HD Patient-Derived Neurons.

Young Mi Oh, Emily A Bacallao, Shin-Ae Lee, Jihyun Kim, Samuel Swinford, Genevieve E Smith, Bryce Britt, Shaymaa Madbouli Abdalla, Seong Won Lee

Abstract read
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In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Young Mi OhDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, 31901, USA.
Emily A BacallaoDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, 31901, USA.
Shin-Ae LeeDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, 31901, USA.
Jihyun KimDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, 31901, USA.
Samuel SwinfordDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, 31901, USA.
Genevieve E SmithDepartment of Biology and Psychology, Mercer University College of Liberal Arts and Sciences, Macon, GA, 31207, USA.
Bryce BrittDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, 31901, USA.
Shaymaa Madbouli AbdallaDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, 31901, USA.
Seong Won LeeDepartment of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, 31901, USA. lee_sw@mercer.edu.ORCID http://orcid.org/0000-0001-8176-9118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a risk factor for neurodegenerative disorders, but the molecular link between neuronal aging and neurodegeneration remains unclear. Huntington's disease (HD) is an inherited neurodegenerative disorder with adult-onset clinical symptoms. Striatal medium spiny neurons (MSNs) are mainly affected in HD, but how aging contributes to MSN degeneration remains uncertain. Using directly converted MSNs from fibroblasts of HD patients (HD-MSNs), we studied age-related pathological features, including neuronal cell death, mutant huntingtin (mHTT) aggregation, and DNA damage in HD. In this study, through transcriptomic analysis of longitudinally aged MSNs and HD-MSNs, we identified four upstream regulators, NFKB1, SOD1, IRF3, and REST, that modulate downstream gene expression in aged MSNs. Among these, knocking down NFKB1 significantly reduced HD pathologies in HD-MSNs, while overexpressing NFKB1 reversed these protective effects. Overall, these results identify NFKB1 as a key age-associated upstream regulator whose downregulation confers neuronal resilience and is a potential therapeutic target in HD.

Indexed as

Age-associated upstream regulatorHuntington’s diseaseMedium spiny neuronsMicroRNA-mediated direct neuronal conversionNeurodegenerationNeurodegenerative diseaseNeuronal agingPatient-derived neurons

Identifiers

PMID42696105

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.