ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Laser speckle flowgraphy (LSFG) in retinal vein occlusion and central serous chorioretinopathy: a systematic review of the recent literature.
Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLaser Speckle Flowgraphy (LSFG) is a non-invasive imaging technology that quantitatively evaluates retinal and choroidal blood flow by analyzing speckle patterns generated by laser light scattering. Compared with OCT-A, which provides detailed visualization of retinal and choroidal microvascular architecture, LSFG offers dynamic quantitative information on ocular blood flow. This systematic review summarizes the application of LSFG in two major vascular diseases: retinal vein occlusion (RVO), and central serous chorioretinopathy (CSCR).
methodsThis second part of a PRISMA-guided systematic review evaluates LSFG in RVO and CSCR, including studies published in English retrieved throughout a comprehensive literature search (2010-2025) conducted in PubMed, Cochrane Library and EMBASE.
resultsTwenty-nine studies (966 eyes: 700 RVO, 266 CSCR) were analyzed. Across retinal vein occlusion, LSFG consistently showed that lower retinal mean blur rate (MBR) associates with higher VEGF/other cytokines, greater ischemia, and worse visual prognosis, while higher baseline or early post-injection MBR predicts better central macular thickness reduction, fewer recurrences, and superior visual recovery. total capillary resistance correlated with clinical severity and visual outcomes. In CSCR, elevated choroidal MBR during the acute phase and its reduction after photodynamic therapy highlighted choroidal hyperperfusion as a key pathogenic mechanism.
conclusionsLSFG captures rapid, reproducible, and non-invasive functional perfusion and vascular-resistance dynamics in RVO and CSCR, complementing OCT-A structural microvascular metrics. Despite heterogeneity and the lack of meta-analysis, LSFG integration into multimodal imaging appears clinically valuable for early diagnosis, risk stratification, treatment monitoring, and the support of individualized care pathways in retinal and choroidal vascular disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.