Evidence map›Paper›PMID 42696006›Full record

ArticleLangenbeck's archives of surgery2026

Outcomes of living donor liver transplantation in elderly Egyptian patients: a retrospective study.

Ahmed Abdelrafee, Mohamed Abdelwahab, Amr Sanad, Ahmed Shehta, Mohamed Eldesoky, Mahmoud A Ali, Mohamed A Elmorshedi, Adel Ali Hassan, Waleed M R Elsarraf

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Article in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Ahmed AbdelrafeeGastrointestinal Surgery Center, Mansoura University, Mansoura, Egypt. ahmad_abdelrafee@mans.edu.eg.ORCID http://orcid.org/0000-0002-7782-357X
Mohamed AbdelwahabGastrointestinal Surgery Center, Mansoura University, Mansoura, Egypt.
Amr SanadGastrointestinal Surgery Center, Mansoura University, Mansoura, Egypt.
Ahmed ShehtaGastrointestinal Surgery Center, Mansoura University, Mansoura, Egypt.
Mohamed EldesokyGastrointestinal Surgery Center, Mansoura University, Mansoura, Egypt.
Mahmoud A AliGastrointestinal Surgery Center, Mansoura University, Mansoura, Egypt.
Mohamed A ElmorshediIntensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Adel Ali HassanAnesthesia and Intensive Care, Faculty of Medicine, Port Said University, Port Said, Egypt.
Waleed M R ElsarrafIntensive Care and Pain Management, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough the results of living donor liver transplantation (LDLT) in the elderly have been reported worldwide, there is still a dearth of information on elderly patients in Egypt. The purpose of this study is to investigate the clinical outcomes of LDLT in this growing population group.

methodsThis was a retrospective study that evaluated all LDLT patients at the Gastrointestinal Surgical Center, Mansoura University, from January 2009 to December 2023. Based on the recipient's age, two patient cohorts were created: younger (< 60) and elderly (≥ 60). Demographics, liver disease etiology, MELD score, surgical duration, blood loss, and early and late post-transplant outcomes (complications, graft survival, and patient survival) were compared between the two groups. Propensity score matching (PSM) was done to improve the baseline covariates imbalance.

resultsAmong 967 LDLT operations, 110 patients were classified in the elderly group (≥ 60 years). Hepatocellular carcinoma (HCC) was markedly more prevalent in the elderly group (44.6% vs. 30.5%, p = 0.002). After PSM analysis, the occurrence of early post-transplant problems was greater in the elderly group (65.5% vs. 51.9%, p = 0.033). Major complications were comparable between both groups (p = 0.763). Importantly, there was no statistically significant difference in 90-day mortality (p = 0.697) or in the 1, 3, and 5-year survival rates (p = 0.660) between the two matched groups.

conclusionLiving donor liver transplantation for carefully selected elderly recipients yields comparable early survival outcomes to younger recipients. However, the elderly cohort faces a significantly higher risk of early morbidity and not statistically significant lower graft survival. Rigorous selection and targeted perioperative care are therefore essential.

Indexed as

Liver TransplantationLiving DonorsAdultAgedAge FactorsCarcinoma, HepatocellularEgyptFemaleGraft SurvivalHumansMaleMiddle AgedPostoperative ComplicationsPropensity ScoreRetrospective StudiesTreatment OutcomeElderly recipientsLiver transplantation outcomesLiving donor liver transplantationPostoperative morbidity

Identifiers

PMID42696006
PMCPMC13545047

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.