Evidence map›Paper›PMID 42695984›Full record

ArticleeLife2026

The insulin/IGF axis is critically important for controlling gene transcription in the podocyte.

Jenny A Hurcombe, Lusyan Dayalan, Fern Barrington, Frederic Burdet, Lan Ni, Joseph Talih Coward, Mark Ibberson, Paul T Brinkkoetter, Martin Holzenberger, Aaron R Jeffries and 3 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jenny A HurcombeBristol Renal, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-4064-7306
Lusyan DayalanBristol Renal, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0003-0821-9149
Fern BarringtonBristol Renal, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0001-7521-7712
Frederic BurdetVital-IT Systems Biology Division, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-2923-827X
Lan NiBristol Renal, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-4733-5081
Joseph Talih CowardBristol Renal, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0009-0004-5416-3099
Mark IbbersonVital-IT Systems Biology Division, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-3152-5670
Paul T BrinkkoetterCluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0002-4287-2080
Martin HolzenbergerINEM, Paris Cité University, Paris, France.ORCID https://orcid.org/0000-0003-4869-725X
Aaron R JeffriesBiosciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.ORCID https://orcid.org/0000-0002-1235-8291
Sebastian OlteanDepartment of Clinical and Biomedical Sciences, Medical School, University of Exeter, Exeter, United Kingdom.
Gavin I WelshBristol Renal, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0002-2148-6658
Richard J M CowardBristol Renal, University of Bristol, Bristol, United Kingdom.ORCID https://orcid.org/0000-0001-6183-2546

Funding

HORIZON EUROPE Health 10.3030/115974Kidney Research UK RP_011_20230628Medical Research Council MR/K010492/1
6 · The paper itself

Abstract

Podocyte integrity depends critically on signalling through the insulin receptor and IGF1 receptor

Indexed as

Gene Expression RegulationInsulinInsulin-Like Growth Factor IPodocytesReceptor, IGF Type 1Receptor, InsulinTranscription, GeneticAnimalsCells, CulturedMiceMice, TransgenicSignal TransductionInsulinInsulin-Like Growth Factor IReceptor, IGF Type 1Receptor, Insulincell biologyhumanIGF1 receptorinsulin receptormousepodocyteRNA processingspliceosome

Identifiers

PMID42695984
PMCPMC13544910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.