Evidence map›Paper›PMID 42695606›Full record

ArticleVirulence2026

A conserved E1 stem motif functions as a virulence switch in the emerging Getah virus.

Zhaoying Xiang, Ganbo Li, Jiayi Wang, Chunpeng Ma, Xinna Ge, Peng Gao, Qiongqiong Zhou, Xin Guo, Lei Zhou, Jun Han and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhaoying XiangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.ORCID 0009-0004-6642-4495
Ganbo LiState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jiayi WangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Chunpeng MaState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Xinna GeState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Peng GaoState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Qiongqiong ZhouState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Xin GuoState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Lei ZhouState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.ORCID 0000-0002-8837-3965
Jun HanState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Yongning ZhangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.ORCID 0000-0002-0134-2761
Hanchun YangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.ORCID 0000-0003-3359-3925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Getah virus (GETV) is an emerging arthropod-borne zoonotic alphavirus that poses a growing threat to animal and public health, yet its virulence determinants remain poorly understood. Here, we report the first identification of a natural GETV variant isolated from the brain of diseased piglets. This variant harbors a 9-nucleotide deletion in the E1 glycoprotein stem region, resulting in the deletion of glutamine 397 (Q397) and valine 398 (V398), along with an asparagine‑to‑isoleucine substitution at position 396 (N396I) and the loss of phenylalanine 399 (F399). It also carries a threonine-to-methionine substitution at position 49 (T49M) in nonstructural protein 2 (NSP2). The NQVF motif (residues 396-399) in E1 protein is highly conserved among GETV strains and related alphaviruses, suggesting a shared functional role. Using reverse genetics, we demonstrated that the E1 deletion-but not the NSP2 mutation-drastically attenuates viral replication

Indexed as

AlphavirusAlphavirus InfectionsSwine DiseasesViral Envelope ProteinsVirulence FactorsAmino Acid MotifsAmino Acid SequenceAnimalsBrainFemaleMiceSequence DeletionSwineVirulenceVirus ReplicationViral Envelope ProteinsVirulence FactorsE1 glycoproteinGetah virus (GETV)nonstructural protein 2 (NSP2)pathogenicityreverse geneticsvirulence determinants

Identifiers

PMID42695606
PMCPMC13556978

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.