ArticleJournal of neuroendocrinology2026
Examining dynamic changes in prefrontal connectivity and internalizing symptoms during the first and third trimesters of pregnancy.
Article in Journal of neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pregnancy is characterized by pronounced neuroplasticity and heightened risk for psychopathology. While previous research has primarily examined postpartum depression, less work has investigated changes in internalizing symptoms measured dimensionally across the peripartum period. Furthermore, limited research has identified functional changes in the prefrontal cortex (PFC) across pregnancy, a brain area implicated in psychopathology. Understanding the dynamic changes in internalizing symptoms and PFC neuroconnectivity throughout pregnancy and their interrelations is crucial for early identification of perinatal psychopathology. This pre-registered longitudinal study examined changes in and associations between internalizing symptoms and PFC functional connectivity throughout the first and third trimesters of pregnancy. Pregnant individuals recruited from a community sample of females engaged in prenatal care (N = 60, M
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