Evidence map›Paper›PMID 42695547›Full record

ArticleMycoses2026

Antifungal Susceptibility Profile and Biocide Tolerance in Clinically Relevant Yeasts: Implications for Therapy and Hospital Infection Control.

Yasmim Passos Lima, Letícia Rebello Machado, Ricardo Villela Bastos, Victor Quinet de Andrade Bastos, Lucas Quinet de Andrade Bastos, André Netto Bastos, Claudio Galuppo Diniz, Vania Lúcia da Silva, Vanessa Cordeiro Dias

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Article in Mycoses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yasmim Passos LimaFederal University of Juiz de Fora - UFJF, Juiz de Fora, MG, Brazil.
Letícia Rebello MachadoFederal University of Juiz de Fora - UFJF, Juiz de Fora, MG, Brazil.
Ricardo Villela BastosCortes Villela Laboratory, Juiz de Fora, MG, Brazil.
Victor Quinet de Andrade BastosCortes Villela Laboratory, Juiz de Fora, MG, Brazil.
Lucas Quinet de Andrade BastosCortes Villela Laboratory, Juiz de Fora, MG, Brazil.
André Netto BastosDepartment of Morphology, Federal University of Juiz de Fora - UFJF, Juiz de Fora, MG, Brazil.
Claudio Galuppo DinizDepartment of Parasitology, Microbiology, and Immunology, Federal University of Juiz de Fora - UFJF, Juiz de Fora, MG, Brazil.
Vania Lúcia da SilvaDepartment of Parasitology, Microbiology, and Immunology, Federal University of Juiz de Fora - UFJF, Juiz de Fora, MG, Brazil.
Vanessa Cordeiro DiasDepartment of Parasitology, Microbiology, and Immunology, Federal University of Juiz de Fora - UFJF, Juiz de Fora, MG, Brazil.ORCID https://orcid.org/0000-0001-7681-3268

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorCortes Villela LaboratoryFundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00995-25Universidade Federal de Juiz de Fora
6 · The paper itself

Abstract

backgroundOpportunistic yeasts account for a substantial proportion of invasive fungal infections and are important agents of healthcare-associated infections, especially in intensive care units (ICUs).

objectivesTo describe the clinical and epidemiological characteristics of hospitalized patients with positive cultures for medically relevant yeasts and correlate these data with antifungal susceptibility, biocide tolerance and phenotypic efflux pump activity.

methodsNinety-four clinical isolates were analysed: 31 Trichosporon asahii, 39 Candida albicans and 24 other yeasts. Antifungal susceptibility and biocide tolerance were assessed by disk diffusion, and phenotypic efflux pump activity was evaluated using ethidium bromide. Clinical and epidemiological data were retrieved from electronic health records.

resultsMost isolates (73.4%) originated from ICUs. Urine (55.3%) was the most frequent clinical specimen. Overall mortality was 62.7%, reaching 71.8% among patients with C. albicans. Notably, 68.1% of patients did not receive antifungal therapy after diagnosis. All T. asahii isolates were susceptible to azoles and resistant to caspofungin. C. albicans showed high susceptibility to amphotericin B (100%) and caspofungin (93%). Phenotypic efflux pump activity was observed in all evaluated yeasts. Sodium hypochlorite showed greater antifungal activity, with inhibition zones of up to 18.0 mm, while hydrogen peroxide (4.25%) and benzalkonium chloride (5%) showed minimal zones (~6 mm) for all isolates.

conclusionsOpportunistic yeast infections continue to pose a major challenge in healthcare settings. Our findings highlight the critical importance of accurate laboratory identification, ongoing surveillance of antifungal susceptibility, and effective infection prevention and control strategies, including the rational selection of biocides, to improve patient outcomes.

Indexed as

Antifungal AgentsCross InfectionDisinfectantsYeastsAgedAmphotericin BBasidiomycotaCandida albicansCaspofunginDrug Resistance, FungalFemaleHumansInfection ControlIntensive Care UnitsMaleMicrobial Sensitivity TestsAmphotericin BAntifungal AgentsCaspofunginDisinfectantsSodium Hypochloriteantifungal resistancebiocides toleranceCandidaefflux pumpinfectiontreatmentTrichosporonyeast

Identifiers

PMID42695547
PMCPMC13543762

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