Evidence map›Paper›PMID 42695511›Full record

ArticleChemistry & biodiversity2026

N-(1H-Indazolyl) Aryl Sulfonamide Hybrids as Potential Dihydropteroate Synthase Inhibitors: In Vitro Antibacterial Activity Against Escherichia coli and Staphylococcus aureus and Computational Modeling.

Romaisaa Boudza, Ferdaous Elandaloussi, Khalid Boujdi, Jaume Segura-Garcia, Nabil El Brahmi, Saïd El Kazzouli, Ismaïl Moukadiri, Sergi Maicas, Salim Bounou

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Romaisaa BoudzaEuromed University of Fes, UEMF, Morocco.ORCID https://orcid.org/0009-0003-6582-2857
Ferdaous ElandaloussiEuromed University of Fes, UEMF, Morocco.
Khalid BoujdiFaculty of Sciences and Techniques of Tangier, Tangier, Morocco.ORCID https://orcid.org/0009-0009-5112-0049
Jaume Segura-GarciaDepartment of Computer Science, School of Engineering, Universitat De València, Burjassot, Spain.ORCID https://orcid.org/0000-0002-9138-5465
Nabil El BrahmiEuromed University of Fes, UEMF, Morocco.ORCID https://orcid.org/0000-0003-1967-2758
Saïd El KazzouliEuromed University of Fes, UEMF, Morocco.ORCID https://orcid.org/0000-0001-5021-3571
Ismaïl MoukadiriEuromed University of Fes, UEMF, Morocco.ORCID https://orcid.org/0000-0002-6557-4430
Sergi MaicasEuromed University of Fes, UEMF, Morocco.ORCID https://orcid.org/0000-0003-4360-611X
Salim BounouEuromed University of Fes, UEMF, Morocco.ORCID https://orcid.org/0000-0001-8312-5420

Funding

Euromed University of Fez
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) has severely compromised the clinical utility of classical sulfonamide antibiotics, primarily owing to the emergence of resistance-associated dihydropteroate synthase variants. In this study, sixteen N-(1H-indazolyl) aryl sulfonamide hybrids were evaluated as potential DHPS inhibitors against Escherichia coli and Staphylococcus aureus using disk diffusion, broth microdilution (MIC

Indexed as

Anti-Bacterial AgentsDihydropteroate SynthaseEnzyme InhibitorsEscherichia coliIndazolesStaphylococcus aureusSulfonamidesDose-Response Relationship, DrugMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsDihydropteroate SynthaseEnzyme InhibitorsIndazolesSulfonamidesADMEantimicrobial resistancedihydropteroate synthasedrug designindazolemolecular dockingsulfonamide

Identifiers

PMID42695511
PMCPMC13543326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.