ArticleJournal of global health2026
Association of pre-pregnancy body mass index and first-trimester remnant cholesterol level with risk of large for gestational age.
Article in Journal of global health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To evaluate the associations of pre-pregnancy body mass index (BMI) and first-trimester remnant cholesterol (RC) level with the risk of large for gestational age (LGA) infants. Methods: A prospective cohort study was conducted in Southeastern China, including 11,319 pregnant women. Logistic regression was used to examine the associations of pre-pregnancy BMI and RC level with LGA. Restricted cubic spline regression was applied to assess the dose-response relationship between RC level and LGA risk. Mediation analysis was performed to evaluate the potential mediation role of gestational diabetes mellitus (GDM) in the associations of pre-pregnancy BMI and RC level with LGA. Results: Compared with the reference groups, LGA risk was significantly higher in women with a pre-pregnancy BMI≥24kg/m Conclusions: Elevated RC and pre-pregnancy BMI are independent LGA risk factors, with minimal GDM mediation. Managing lipid profiles, particularly RC, is important even in high-BMI women.
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